Abby received her bachelor’s degree in chemistry from Hope College in 2005, and her PhD in biochemistry with Phyllis Hanson at Washington University in St. Louis in 2011. She completed postdoctoral training with Martin Hetzer at the Salk Institute in 2018, and joined the faculty at UCSF CVRI in the fall of 2018.
O her work, Dr Buckwalter Cool states that this work begins with a particular focus on the nuclear lamina, a nuclear structure that is essential for mammalian development and is mutated in ~15 "laminopathy" diseases that afflict the heart, muscle, bone, fat, and nervous system. We focus on three main thematic areas: (i) defining the essential roles that the nuclear lamina plays in nuclear organization, (ii) exploring disruption of nuclear organization as a possible cellular mechanism of aging, and (iii) determining how nuclear organization is maintained or, alternatively, remodeled, over time. We use cell biology, biochemistry, and systems biology to answer these questions. For more information about this talk, or the rest of the Biology Colloquium, go to https://biology.sonoma.edu/colloquium or email biology@sonoma.edu
