Associate Professor of Biology
Ph.D. University of California, San Francisco, 2003
Voicemail: (707) 664-2931
Office: Darwin 211
Washington University in Saint Louis.
Molecular and Cellular Biology, Signal Transduction,
My research efforts focus on how cells of the immune system, specifically T cells, are activated to protect us from pathogens. T cells are vital for the establishment of protective immunity in response to vaccination and subsequent infection. Their activation requires a delicate balance between having the sensitivity to respond to low levels of pathogens, but at the same time, not respond to "self" which would lead to the development of autoimmune diseases such as lupus or rheumatoid arthritis.
In particular, I am interested in the intracellular signaling pathways that are responsible for T cell activation. This complex process involves the dynamic interplay between a multitude of signaling molecules, ultimately resulting in differentiation and proliferation. By taking a molecular and biochemical approach to dissecting the intricate pathways required for T cell activation, we hope to further understand these complicated mechanisms and determine how loss of regulation can lead to various disease states.
Jackson, M.L., Fields, H.F., Lujan, T.S., Cantrell, M.M., Lin, J., and Fukuto J.M. (2013) The Effects of Nitroxyl (HNO) on H2O2 Metabolism and Possible Mechanisms of HNO Signaling. Arch Biochem Biophys. (In Press).
Katsumoto, T.R., Kudo, M., Callahan, E.C., Zhu, J.W., Lin, J., Rosen, C.E., Manz, B., Lee, J.W., Matthay, M.A., Huang, X., Sheppard, D., and Weiss, A. (2013) The phosphatase CD148 promotes airway hyperresponsiveness by positively regulating Src family kinases. J Clin Invest. 123(5): 2037-48.
Filbert, E.L., Le Borgne, M., Lin, J., Heuser, J.E., and Shaw, A.S. (2012) Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells. J Immunol. 188(11): 5421-7.
Whitacre, J.M., Lin, J., Harding, A. (2012) T cell adaptive immunity proceeds through environment-induced adaptation from the exposure of cryptic genetic variation. Front Genet. 3:5.
Lin, J. and Weiss, A. (2010) Proximal tyrosine kinases that initiate T cell activation. Nature Reviews Immunology, 10(3). This peer-reviewed publication appeared as a poster-sized insert in the March 2010 issue of NRI.
Lin, J., Hou, K.K., Piwnica-Worms, H., and Shaw, A.S. (2009) The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced MTOC polarization. J Immunol. 183:1215-21.
Lin, J., Harding, A., Giurisato, E., and Shaw, A.S. (2009) KSR modulates the sensitivity of the MAPK pathway in T cells without altering fundamental system outputs. Mol Cell Biol. 29:2082-91.
Zhu, J.W., Brdicka, R., Katsumoto, T.R., Lin, J., and Weiss, A. (2008) Structurally distinct receptor-type protein tyrosine phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity. 28:183-196.
Lin, J., and Shaw, A.S. (2005) Getting downstream without a raft. Cell. 121:815-816.
Lin, J., Zhu, J.W., Baker, J.E., and Weiss, A. (2004) Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells. J Immunol. 173:2324-2330.
Lin, J., and Weiss, A. (2003) The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol. 162:673-682.
Lin, J., and Weiss, A. (2001) Identification of the minimal tyrsine residues required for linker for activation of T cell function. J Biol Chem. 276:29588-29595.
Lin, J., and Weiss, A. (2001) T cell receptor signalling. J Cell Sci. 114:243-244.
Lin, J., Weiss, A., and Finco, T.S. (1999) Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J Biol Chem. 274:28861-28864
Introductory Genetics and Cell Biology (Biol 130A), Molecular and Cell Biology (Biol 123), Biology of Cancer (Biol 309), Virology (Biol 383), Immunology (Biol 480), Advanced Molecular and Cellular Techniques (Biol 497R), Advanced Cell Biology (Biol 544)